In 1503, Leonardo da Vinci was commissioned to paint a young woman's portrait, but he never gave it to her. That woman was Lisa Gherardini, the real Mona Lisa. Now after five hundred years she has come back to get her portrait. MONA LISA'S GHOST, is a mystery, is the sequel to The Crystal Navigator. One of Lucy's classemates claims to be the reincarnation of Lisa and she is going to steal her painting. When the Mona Lisa vanishes, Lucy and her genius friend Sam solve a mystery that would stun the world if it were ever made public.
During a class video about the Mona Lisa, Lucy Nightingale and her best friend, Sam Winter notice that the painting seems to be melting. Sam thinks it has been attacked by a molecule-destroying syndrome called Zoom Seizure. On winter vacation, Lucy and her parents go to Paris where she can investigate. In the Mona Lisa Gallery of the Louvre Museum, Lucy bumps into Melissa Blackwood, a classmate from home. Melissa shocks Lucy telling her that she is the reincarnation of Mona Lisa and that she has come back to steal the painting. That night, the painting is mysteriously stolen and Lucy must find it before Zoom Seizure destroys it. In an adventure that takes Lucy through the ghost-infested Catacombs of Paris, down underground rivers, and back to sixteenth-century France. This coming-of-age series is sure to entertain and inspire young readers as Lucy learns to trust her intuition, see herself, others, and the world around her with greater clarity, and to believe in the magic that lies inside every one of us.